Ontology highlight
ABSTRACT:
SUBMITTER: Feng H
PROVIDER: S-EPMC5690873 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Feng Hui H Lenarcic Erik M EM Yamane Daisuke D Wauthier Eliane E Mo Jinyao J Guo Haitao H McGivern David R DR González-López Olga O Misumi Ichiro I Reid Lola M LM Whitmire Jason K JK Ting Jenny P-Y JP Duncan Joseph A JA Moorman Nathaniel J NJ Lemon Stanley M SM
Nature immunology 20171002 12
NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiviral responses. We found that NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3, which might potentially explain such contradi ...[more]