Ontology highlight
ABSTRACT:
SUBMITTER: Pitre A
PROVIDER: S-EPMC5691054 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pitre Aaron A Ge Yubin Y Lin Wenwei W Wang Yao Y Fukuda Yu Y Temirov Jamshid J Phillips Aaron H AH Peters Jennifer L JL Fan Yiping Y Ma Jing J Nourse Amanda A Sinha Chandrima C Lin Hai H Kriwacki Richard R Downing James R JR Gruber Tanja A TA Centonze Victoria E VE Naren Anjaparavanda P AP Chen Taosheng T Schuetz John D JD
Nature communications 20171116 1
The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated with worse overall survival in AML. Murine hematopoietic progenitor cells overexpressing MPP1 acquired the ability to serially replate in methylcellulose culture, a property crucially dependent upon ABC ...[more]