Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure.
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ABSTRACT:
SUBMITTER: Chen CH
PROVIDER: S-EPMC5691156 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure.
Chen Chi-Hua CH Wang Yunpeng Y Lo Min-Tzu MT Schork Andrew A Fan Chun-Chieh CC Holland Dominic D Kauppi Karolina K Smeland Olav B OB Djurovic Srdjan S Sanyal Nilotpal N Hibar Derrek P DP Thompson Paul M PM Thompson Wesley K WK Andreassen Ole A OA Dale Anders M AM
Scientific reports 20171116 1
Discovering genetic variants associated with human brain structures is an on-going effort. The ENIGMA consortium conducted genome-wide association studies (GWAS) with standard multi-study analytical methodology and identified several significant single nucleotide polymorphisms (SNPs). Here we employ a novel analytical approach that incorporates functional genome annotations (e.g., exon or 5'UTR), total linkage disequilibrium (LD) scores and heterozygosity to construct enrichment scores for impro ...[more]
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