Ontology highlight
ABSTRACT:
SUBMITTER: Rai TS
PROVIDER: S-EPMC5691367 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Rai Taranjit Singh TS Glass Mandy M Cole John J JJ Rather Mohammad I MI Marsden Morgan M Neilson Matthew M Brock Claire C Humphreys Ian R IR Everett Roger D RD Adams Peter D PD
Nucleic acids research 20171101 20
The HIRA histone chaperone complex deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independent manner. As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex affects herpesvirus infection. After infection of primary cells with HSV or CMV, or transient transfection with naked plasmid DNA, HIRA re-localizes to PML bodies, sites of cellular anti-viral activity. HIRA co-localizes with viral genomes, binds to incoming viral and pla ...[more]