Meta-analysis of Liver and Heart Transcriptomic Data for Functional Annotation Transfer in Mammalian Orthologs.
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ABSTRACT:
SUBMITTER: Reyes PFL
PROVIDER: S-EPMC5691612 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Meta-analysis of Liver and Heart Transcriptomic Data for Functional Annotation Transfer in Mammalian Orthologs.
Reyes Pía Francesca Loren PFL Michoel Tom T Joshi Anagha A Devailly Guillaume G
Computational and structural biotechnology journal 20170826
Functional annotation transfer across multi-gene family orthologs can lead to functional misannotations. We hypothesised that co-expression network will help predict functional orthologs amongst complex homologous gene families. To explore the use of transcriptomic data available in public domain to identify functionally equivalent ones from all predicted orthologs, we collected genome wide expression data in mouse and rat liver from over 1500 experiments with varied treatments. We used a hyper- ...[more]
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