Ontology highlight
ABSTRACT:
SUBMITTER: Kvansakul M
PROVIDER: S-EPMC5691641 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kvansakul Marc M Caria Sofia S Hinds Mark G MG
Viruses 20171006 10
Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bc ...[more]