Ontology highlight
ABSTRACT:
SUBMITTER: Hu H
PROVIDER: S-EPMC5692532 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hu Hengxun H Nan Jinliang J Sun Yong Y Zhu Dan D Xiao Changchen C Wang Yaping Y Zhu Lianlian L Wu Yue Y Zhao Jing J Wu Rongrong R Chen Jinghai J Yu Hong H Hu Xinyang X Zhu Wei W Wang Jian'an J
Proceedings of the National Academy of Sciences of the United States of America 20171020 45
The causative relationship between specific mitochondrial molecular structure and reactive oxygen species (ROS) generation has attracted much attention. NDUFA13 is a newly identified accessory subunit of mitochondria complex I with a unique molecular structure and a location that is very close to the subunits of complex I of low electrochemical potentials. It has been reported that down-regulated NDUFA13 rendered tumor cells more resistant to apoptosis. Thus, this molecule might provide an ideal ...[more]