Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT_1A [¹¹C]CUMI-101 PET and Functional MRI Study.

ABSTRACT: A subset of patients started on a selective serotonin reuptake inhibitor (SSRI) initially experience increased anxiety, which can lead to early discontinuation before therapeutic effects are manifest. The neural basis of this early SSRI effect is not known. Presynaptic dorsal raphe neuron (DRN) 5-HT_1A receptors are known to have a critical role in affect processing. Thus we investigated the effect of acute citalopram on emotional processing and the relationship between DRN 5-HT_1A receptor availability and amygdala reactivity. Thirteen (mean age 48±9 years) healthy male subjects received either a saline or citalopram infusion intravenously (10 mg over 30 min) on separate occasions in a single-blind, random order, crossover design. On each occasion, participants underwe

SUBMITTER: Selvaraj S 

PROVIDER: S-EPMC5693328 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature