Effect of smokeless tobacco products on human oral bacteria growth and viability.

ABSTRACT: To evaluate the toxicity of smokeless tobacco products (STPs) on oral bacteria, seven smokeless tobacco aqueous extracts (STAEs) from major brands of STPs and three tobacco-specific N-nitrosamines (TSNAs) were used in a growth and viability test against 38 oral bacterial species or subspecies. All seven STAEs showed concentration-dependent effects on the growth and viability of tested oral bacteria under anaerobic culture conditions, although there were strain-to-strain variations. In the presence of 1 mg/ml STAEs, the growth of 4 strains decreased over 0.32-2.14 log₁₀ fold, while 14 strains demonstrated enhanced growth of 0.3-1.76 log₁₀ fold, and the growth of 21 strains was not significantly affected. In the presence of 10 mg/ml STAEs, the growth of 17 strains was i

SUBMITTER: Liu M 

PROVIDER: S-EPMC5693344 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature