Dataset Information

Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.

ABSTRACT: Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.

SUBMITTER: Mitra A

PROVIDER: S-EPMC5693436 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.

Mitra Anish A Snyder Abraham Z AZ Tagliazucchi Enzo E Laufs Helmut H Elison Jed J Emerson Robert W RW Shen Mark D MD Wolff Jason J JJ Botteron Kelly N KN Dager Stephen S Estes Annette M AM Evans Alan A Gerig Guido G Hazlett Heather C HC Paterson Sarah J SJ Schultz Robert T RT Styner Martin A MA Zwaigenbaum Lonnie L Schlaggar Bradley L BL Piven Joseph J Pruett John R JR Raichle Marcus M

PloS one 20171117 11

Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especi ...[more]

PMID: 29149191

Similar Datasets

Project description:BACKGROUND:Drifts between wakefulness and sleep are common during resting state functional MRI (rsfMRI). Among healthy adults, within-scanner sleep can impact functional connectivity of default mode (DMN), task-positive (TPN), and thalamo-cortical networks. Because dysfunctional arousal states (i.e., sleepiness, sleep disturbance) are common in affective disorders, individuals with affective psychopathology may be more prone to unstable wakefulness during rsfMRI, hampering the estimation of clinically meaningful functional connectivity biomarkers. METHODS:A transdiagnostic sample of 150 young adults (68 psychologically distressed; 82 psychiatrically healthy) completed rsfMRI and reported whether they experienced within-scanner sleep. Symptom scales were reduced into depression/anxiety and mania proneness dimensions using principal component analysis. We evaluated associations between within-scanner sleep, clinical status, and functional connectivity of the DMN, TPN, and thalamus. RESULTS:Within-scanner sleep during rsfMRI was reported by 44% of participants (n?=?66) but was unrelated to psychiatric diagnoses or mood symptom severity (p-values > 0.05). Across all participants, self-reported within-scanner sleep was associated with connectivity signatures akin to objectively-assessed sleep, including lower within-DMN connectivity, lower DMN-TPN anti-correlation, and altered thalamo-cortical connectivity (p < 0.05, corrected). Among participants reporting sustained wakefulness (n?=?84), depression/anxiety severity positively associated with averaged DMN-TPN connectivity and mania proneness negatively associated with averaged thalamus-DMN connectivity (p-values < 0.05). Both relationships were attenuated and became non-significant when participants reporting within-scanner sleep were included (p-values > 0.05). LIMITATIONS:Subjective report of within-scanner sleep. CONCLUSIONS:Findings implicate within-scanner sleep as a source of variance in network connectivity; careful monitoring and correction for within-scanner sleep may enhance our ability to characterize network signatures underlying affective psychopathology.

Dataset Information

Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.

Publications

Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets