Ontology highlight
ABSTRACT:
SUBMITTER: Talay M
PROVIDER: S-EPMC5693608 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Talay Mustafa M Richman Ethan B EB Snell Nathaniel J NJ Hartmann Griffin G GG Fisher John D JD Sorkaç Altar A Santoyo Juan F JF Chou-Freed Cambria C Nair Nived N Johnson Mark M Szymanski John R JR Barnea Gilad G
Neuron 20171026 4
Mapping neural circuits across defined synapses is essential for understanding brain function. Here we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulation. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at t ...[more]