Ontology highlight
ABSTRACT:
SUBMITTER: Carpino G
PROVIDER: S-EPMC5693899 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Carpino Guido G Pastori Daniele D Baratta Francesco F Overi Diletta D Labbadia Giancarlo G Polimeni Licia L Di Costanzo Alessia A Pannitteri Gaetano G Carnevale Roberto R Del Ben Maria M Arca Marcello M Violi Francesco F Angelico Francesco F Gaudio Eugenio E
Scientific reports 20171117 1
Pathogenesis of non-alcoholic fatty liver disease (NAFLD) is influenced by predisposing genetic variations, dysmetabolism, systemic oxidative stress, and local cellular and molecular cross-talks. Patatin-like phospholipase domain containing 3 (PNPLA3) gene I148M variant is a known determinant of NAFLD. Aims were to evaluate whether PNPLA3 I148M variant was associated with a specific histological pattern, hepatic stem/progenitor cell (HpSC) niche activation and serum oxidative stress markers. Liv ...[more]