Ontology highlight
ABSTRACT:
SUBMITTER: Shalev-Benami M
PROVIDER: S-EPMC5693986 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171117 1
Leishmania is a single-celled eukaryotic parasite afflicting millions of humans worldwide, with current therapies limited to a poor selection of drugs that mostly target elements in the parasite's cell envelope. Here we determined the atomic resolution electron cryo-microscopy (cryo-EM) structure of the Leishmania ribosome in complex with paromomycin (PAR), a highly potent compound recently approved for treatment of the fatal visceral leishmaniasis (VL). The structure reveals the mechanism by wh ...[more]