Decoding HIV resistance: from genotype to therapy.
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ABSTRACT:
SUBMITTER: Weber IT
PROVIDER: S-EPMC5694023 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Decoding HIV resistance: from genotype to therapy.
Weber Irene T IT Harrison Robert W RW
Future medicinal chemistry 20170809 13
Genetic variation in HIV poses a major challenge for prevention and treatment of the AIDS pandemic. Resistance occurs by mutations in the target proteins that lower affinity for the drug or alter the protein dynamics, thereby enabling viral replication in the presence of the drug. Due to the prevalence of drug-resistant strains, monitoring the genotype of the infecting virus is recommended. Computational approaches for predicting resistance from genotype data and guiding therapy are discussed. M ...[more]
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