Ontology highlight
ABSTRACT:
SUBMITTER: Ackermann MA
PROVIDER: S-EPMC5694667 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ackermann Maegen A MA King Brendan B Lieberman Nicole A P NAP Bobbili Prameela J PJ Rudloff Michael M Berndsen Christopher E CE Wright Nathan T NT Hecker Peter A PA Kontrogianni-Konstantopoulos Aikaterini A
Journal of molecular and cellular cardiology 20170804
The intercalated disc of cardiac muscle embodies a highly-ordered, multifunctional network, essential for the synchronous contraction of the heart. Over 200 known proteins localize to the intercalated disc. The challenge now lies in their characterization as it relates to the coupling of neighboring cells and whole heart function. Using molecular, biochemical and imaging techniques, we characterized for the first time two small obscurin isoforms, obscurin-40 and obscurin-80, which are enriched a ...[more]