Ontology highlight
ABSTRACT:
SUBMITTER: Kondo S
PROVIDER: S-EPMC5695085 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kondo Shu S Vedanayagam Jeffrey J Mohammed Jaaved J Eizadshenass Sogol S Kan Lijuan L Pang Nan N Aradhya Rajaguru R Siepel Adam A Steinhauer Josefa J Lai Eric C EC
Genes & development 20170901 18
Relatively little is known about the in vivo functions of newly emerging genes, especially in metazoans. Although prior RNAi studies reported prevalent lethality among young gene knockdowns, our phylogenomic analyses reveal that young <i>Drosophila</i> genes are frequently restricted to the nonessential male reproductive system. We performed large-scale CRISPR/Cas9 mutagenesis of "conserved, essential" and "young, RNAi-lethal" genes and broadly confirmed the lethality of the former but the viabi ...[more]