Ontology highlight
ABSTRACT:
SUBMITTER: Caffrey-Carr AK
PROVIDER: S-EPMC5695118 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Caffrey-Carr Alayna K AK Kowalski Caitlin H CH Beattie Sarah R SR Blaseg Nathan A NA Upshaw Chanell R CR Thammahong Arsa A Lust Hannah E HE Tang Yi-Wei YW Hohl Tobias M TM Cramer Robert A RA Obar Joshua J JJ
Infection and immunity 20171117 12
Heterogeneity among <i>Aspergillus fumigatus</i> isolates results in unique virulence potential and inflammatory responses. How these isolates drive specific immune responses and how this affects fungally induced lung damage and disease outcome are unresolved. We demonstrate that the highly virulent CEA10 strain is able to rapidly germinate within the immunocompetent lung environment, inducing greater lung damage, vascular leakage, and interleukin 1α (IL-1α) release than the low-virulence Af293 ...[more]