Dataset Information

Association between visceral obesity and hepatitis C infection stratified by gender: a cross-sectional study in Taiwan.

ABSTRACT:

Objectives

The global prevalence of hepatitis C virus (HCV) is approximately 2%-3%, and the prevalence of the positive anti-HCV antibody has been increasing. Several studies have evaluated regional adipose tissue distribution and metabolism over the past decades. However, no study has focused on the gender difference in visceral obesity among patients with HCV infection.

Design

Retrospective cross-sectional study.

Setting

We reviewed the medical records of patients who visited a hospital in Southern Taiwan for health check-up from 2013 to 2015.

Participants

A total of 1267 medical records were collected. We compared patient characteristics, variables related to metabolic risk and body composition measured using bioelectrical impedance analysis between the groups. Regression models were built to adjust for possible confounding factors.

Results

The prevalence rate of the positive anti-HCV antibody was 8.8% in the study population, 8.5% in men and 9.2% in women. Men with HCV infection tended to be older and have lower total cholesterol levels and higher alanine aminotransferase (ALT) levels (p<0.001). Women with HCV infection tended to be older and have higher levels of fasting glucose and ALT (p<0.001). After adjusting for confounding factors, body fat percentage, fat-free mass/body weight (BW) and muscle mass/BW were found to be the independent determinants of visceral obesity in patients without HCV infection (p<0.001). However, the trend was not such obvious in patients with HCV infection, though still statistically significant (p<0.05). Furthermore, the trend was less significant in men with HCV infection.

Conclusions

The findings suggested that HCV modulates host lipid metabolism and distribution to some extent, and a gender difference was also noted.

SUBMITTER: Tsao YC

PROVIDER: S-EPMC5695385 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Association between visceral obesity and hepatitis C infection stratified by gender: a cross-sectional study in Taiwan.

Tsao Yu-Chung YC Chen Jau-Yuan JY Yeh Wei-Chung WC Peng Yun-Shing YS Li Wen-Cheng WC

BMJ open 20171112 11

<h4>Objectives</h4>The global prevalence of hepatitis C virus (HCV) is approximately 2%-3%, and the prevalence of the positive anti-HCV antibody has been increasing. Several studies have evaluated regional adipose tissue distribution and metabolism over the past decades. However, no study has focused on the gender difference in visceral obesity among patients with HCV infection.<h4>Design</h4>Retrospective cross-sectional study.<h4>Setting</h4>We reviewed the medical records of patients who visi ...[more]

PMID: 29133317

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Project description:BackgroundPrevious studies have revealed the effects of different physical activity (PA) types on visceral adipose tissue (VAT) accumulation in individuals with overweight/obesity. However, the independent association (especially the dose-response relationship) between PA and VAT in individuals with and without overweight/obesity remains less explored. Visceral adiposity index (VAI), calculated from waist circumference, body mass index (BMI), triglyceride and high-density lipoprotein cholesterol, is a novel indicator of VAT. This study aims to elucidate the association between PA and VAI in participants with and without overweight/obesity.MethodsParticipants who are overweight or obese and with complete data on VAI, PA, and other essential covariates from the National Health and Nutrition Examination Survey (NHANES) database (2015-2018) were included in this study. PA was evaluated by the PA questionnaire and converted into metabolic equivalent task (MET) hours per week (MET-h/wk) based on the suggested MET scores. Multivariate linear regression models were used to identify the association between PA and VAI. Subgroup analyses, combined with interaction tests and restricted cubic spline (RCS) regression analyses, were utilized to explore the stability and nonlinearity of PA-VAI association, respectively.ResultsA total of 4, 312 participants with complete data on PA and VAI was included in this study, with 3, 441 of them being overweight or obese. After adjusting for all potential covariates, increased PA was found to be significantly associated with remarkable lower level of VAI in all participants (β = -0.0004, P = 0.003), participants with (β = -0.0013, P = 0.012) and without (β = -0.0004, P = 0.003) overweight/obesity. Subgroup analyses and interaction tests revealed that the PA-VAI association was not modified by other covariates in individuals with overweight/obesity. Furthermore, RCS analyses revealed that PA was significantly, linearly and negatively associated with VAI in all participants, participants with and without overweight/obesity (all P < 0.05, all P for nonlinearity > 0.05). Noteworthily, as opposed to individuals without overweight/obesity, PA was significantly associated with lower VAI in participants with overweight/obesity after exceeding the threshold of 150 MET-h/wk.ConclusionIncreased PA was significantly associated with lower level of VAI, but a higher level of PA (> 150 MET-h/wk) was needed to obtain significantly lower level of VAI in individuals with overweight/obesity.

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Dataset Information

Association between visceral obesity and hepatitis C infection stratified by gender: a cross-sectional study in Taiwan.

Objectives

Design

Setting

Participants

Results

Conclusions

Publications

Association between visceral obesity and hepatitis C infection stratified by gender: a cross-sectional study in Taiwan.

Similar Datasets

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