Ontology highlight
ABSTRACT:
SUBMITTER: Saravanan S
PROVIDER: S-EPMC5695734 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Saravanan Shanmugam S Kausalya Bagavathi B Gomathi Selvamurthi S Sivamalar Sathasivam S Pachamuthu Balakrishnan B Selvamuthu Poongulali P Pradeep Amrose A Sunil Solomon S Mothi Sarvode N SN Smith Davey M DM Kantor Rami R
AIDS research and human retroviruses 20161223 6
We have analyzed reverse transcriptase (RT) region of HIV-1 pol gene from 97 HIV-infected children who were identified as failing first-line therapy that included first-generation non-nucleoside RT inhibitors (Nevirapine and Efavirenz) for at least 6 months. We found that 54% and 65% of the children had genotypically predicted resistance to second-generation non-nucleoside RT inhibitors drugs Etravirine (ETR) and Rilpivirine, respectively. These cross-resistance mutations may compromise future N ...[more]