Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia.

ABSTRACT: Current hypotheses stipulate core symptoms of schizophrenia (SZ) result from the brain's incapacity to integrate neural processes. Converging diffusion magnetic resonance imaging and graph theory studies provide evidence of macrostructural alterations in SZ. However, age-related topological changes within and between white matter (WM) networks and its relationship to gene expression with disease progression remain incompletely understood. This cross-sectional study uses network modeling to investigate changes in WM network organization with disease progression in chronic SZ as well its relationship with gene expression in healthy brains. First, we replicate prior findings demonstrating altered global WM network topology in SZ. Novel results show significantly altered age-related network de

SUBMITTER: Powell F 

PROVIDER: S-EPMC5695754 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature