The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
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ABSTRACT:
SUBMITTER: Clarke K
PROVIDER: S-EPMC5695912 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Clarke Kim K Ricciardi Sara S Pearson Tim T Bharudin Izwan I Davidsen Peter K PK Bonomo Michela M Brina Daniela D Scagliola Alessandra A Simpson Deborah M DM Beynon Robert J RJ Khanim Farhat F Ankers John J Sarzynski Mark A MA Ghosh Sujoy S Pisconti Addolorata A Rozman Jan J Hrabe de Angelis Martin M Bunce Chris C Stewart Claire C Egginton Stuart S Caddick Mark M Jackson Malcolm M Bouchard Claude C Biffo Stefano S Falciani Francesco F
Cell reports 20171101 6
Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling, we show that endurance training induces profound changes in gene regulatory networks linking signaling and selective control of translation to energy metabolism and tissue remodeling. We discovered that knockdown of the mTOR-independent factor Eif6, which we ...[more]
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