Ontology highlight
ABSTRACT:
SUBMITTER: Akinrotimi O
PROVIDER: S-EPMC5696047 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Akinrotimi Oludemilade O Riessen Ryan R VanDuyne Philip P Park Jung Eun JE Lee Yoon Kwang YK Wong Lee-Jun LJ Zavacki Ann M AM Schoonjans Kristina K Anakk Sayeepriyadarshini S
Hepatology (Baltimore, Md.) 20171030 6
Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are important regulators of bile acid, lipid, and glucose homeostasis. Here, we show that global Fxr <sup>-/-</sup> Shp<sup>-/-</sup> double knockout (DKO) mice are refractory to weight gain, glucose intolerance, and hepatic steatosis when challenged with high-fat diet. DKO mice display an inherently increased capacity to burn fat and suppress de novo hepatic lipid synthesis. Moreover, DKO mice were also very active ...[more]