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A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues.

ABSTRACT: Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can be efficiently numbered up to increase throughput two orders of magnitude greater than the corresponding batch reactions.

SUBMITTER: Yueh H

PROVIDER: S-EPMC5696104 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues.

Yueh Han H Gao Qiwen Q Porco John A JA Beeler Aaron B AB

Bioorganic & medicinal chemistry 20170611 23

Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can be efficiently numbered up to increase throughput two orders of magnitude greater than the corresponding batch reactions. ...[more]

PMID: 28666859

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