Immuno-PET imaging based radioimmunotherapy in head and neck squamous cell carcinoma model.

ABSTRACT: The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent and acquired resistance are serious problems and are responsible for limited clinical efficacy and tumor recurrence. In this study, we evaluated the feasibility of immuno-positron emission tomography (PET) imaging and radioimmunotherapy (RIT) with ⁶⁴Cu-/¹⁷⁷Lu-PCTA-cetuximab in cetuximab-resistant SNU-1066 HNSCC xenografted model. The cellular uptake of ⁶⁴Cu/¹⁷⁷Lu-3,6,9,15-tetraazabicyclo[9.3.1]-pentadeca-1(15),11,13-triene-3,6,9,-triacetic acid (PCTA)-cetuximab showed good correlation with western blot and flow cytometry analysis in EGFR expression level of various HNSCC cells

SUBMITTER: Song IH 

PROVIDER: S-EPMC5696166 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature