Ontology highlight
ABSTRACT:
SUBMITTER: Maschalidi S
PROVIDER: S-EPMC5696382 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Maschalidi Sophia S Nunes-Hasler Paula P Nascimento Clarissa R CR Sallent Ignacio I Lannoy Valérie V Garfa-Traore Meriem M Cagnard Nicolas N Sepulveda Fernando E FE Vargas Pablo P Lennon-Duménil Ana-Maria AM van Endert Peter P Capiod Thierry T Demaurex Nicolas N Darrasse-Jèze Guillaume G Manoury Bénédicte B
Nature communications 20171121 1
Dendritic cells (DC) have the unique ability to present exogenous antigens via the major histocompatibility complex class I pathway to stimulate naive CD8<sup>+</sup> T cells. In DCs with a non-functional mutation in Unc93b1 (3d mutation), endosomal acidification, phagosomal maturation, antigen degradation, antigen export to the cytosol and the function of the store-operated-Ca<sup>2+</sup>-entry regulator STIM1 are impaired. These defects result in compromised antigen cross-presentation and ant ...[more]