Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer.
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ABSTRACT:
SUBMITTER: Doddapaneni R
PROVIDER: S-EPMC5696458 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer.
Doddapaneni Ravi R Patel Ketan K Chowdhury Nusrat N Singh Mandip M
Scientific reports 20171120 1
Multidrug resistance (MDR) is a major impediment to cancer treatment. Here, for the first time, we investigated the chemo-sensitizing effect of Noscapine (Nos) at low concentrations in conjunction with docetaxel (DTX) to overcome drug resistance of triple negative breast cancer (TNBC). In vitro experiments showed that Nos significantly inhibited proliferation of TNBC wild type (p < 0.01) and drug resistant (p < 0.05) TNBC cells. Nos followed by DTX treatment notably increased the cell viability ...[more]
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