Ontology highlight
ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC5696522 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20171120 1
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility ...[more]