Ontology highlight
ABSTRACT:
SUBMITTER: Thimsen V
PROVIDER: S-EPMC5696533 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Thimsen Vivian V John Nora N Buchfelder Michael M Flitsch Jörg J Fahlbusch Rudolf R Stefanits Harald H Knosp Engelbert E Losa Marco M Buslei Rolf R Hölsken Annett A
Scientific reports 20171120 1
Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this study we analysed the expression of both transcription factors using immunohistochemistry in a large cohort of 64 adamantinomatous (aCP) and 9 papillary CP (pCP) and quantitative PCR in 26 aCP and 7 pCP. Whereas immunohistochemically Sox2+ cells we ...[more]