Ontology highlight
ABSTRACT:
SUBMITTER: Carlin AF
PROVIDER: S-EPMC5696617 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Carlin Aaron F AF Plummer Emily M EM Vizcarra Edward A EA Sheets Nicholas N Joo Yunichel Y Tang William W Day Jeremy J Greenbaum Jay J Glass Christopher K CK Diamond Michael S MS Shresta Sujan S
Cell reports 20171101 6
Interferon-regulatory factors (IRFs) are a family of transcription factors (TFs) that translate viral recognition into antiviral responses, including type I interferon (IFN) production. Dengue virus (DENV) and other clinically important flaviviruses are suppressed by type I IFN. While mice lacking the type I IFN receptor (Ifnar1<sup>-/-</sup>) succumb to DENV infection, we found that mice deficient in three transcription factors controlling type I IFN production (Irf3<sup>-/-</sup>Irf5<sup>-/-</ ...[more]