Dataset Information

Multiparametric MRI changes persist beyond recovery in concussed adolescent hockey players.

ABSTRACT:

Objective

To determine whether multiparametric MRI data can provide insight into the acute and long-lasting neuronal sequelae after a concussion in adolescent athletes.

Methods

Players were recruited from Bantam hockey leagues in which body checking is first introduced (male, age 11-14 years). Clinical measures, diffusion metrics, resting-state network and region-to-region functional connectivity patterns, and magnetic resonance spectroscopy absolute metabolite concentrations were analyzed from an independent, age-matched control group of hockey players (n = 26) and longitudinally in concussed athletes within 24 to 72 hours (n = 17) and 3 months (n = 14) after a diagnosed concussion.

Results

There were diffusion abnormalities within multiple white matter tracts, functional hyperconnectivity, and decreases in choline 3 months after concussion. Tract-specific spatial statistics revealed a large region along the superior longitudinal fasciculus with the largest decreases in diffusivity measures, which significantly correlated with clinical deficits. This region also spatially intersected with probabilistic tracts connecting cortical regions where we found acute functional connectivity changes. Hyperconnectivity patterns at 3 months after concussion were present only in players with relatively less severe clinical outcomes, higher choline concentrations, and diffusivity indicative of relatively less axonal disruption.

Conclusions

Changes persisted well after players' clinical scores had returned to normal and they had been cleared to return to play. Ongoing white matter maturation may make adolescent athletes particularly vulnerable to brain injury, and they may require extended recovery periods. The consequences of early brain injury for ongoing brain development and risk of more serious conditions such as second impact syndrome or neural degenerative processes need to be elucidated.

SUBMITTER: Manning KY

PROVIDER: S-EPMC5696642 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Multiparametric MRI changes persist beyond recovery in concussed adolescent hockey players.

Manning Kathryn Y KY Schranz Amy A Bartha Robert R Dekaban Gregory A GA Barreira Christy C Brown Arthur A Fischer Lisa L Asem Kevin K Doherty Timothy J TJ Fraser Douglas D DD Holmes Jeff J Menon Ravi S RS

Neurology 20171025 21

<h4>Objective</h4>To determine whether multiparametric MRI data can provide insight into the acute and long-lasting neuronal sequelae after a concussion in adolescent athletes.<h4>Methods</h4>Players were recruited from Bantam hockey leagues in which body checking is first introduced (male, age 11-14 years). Clinical measures, diffusion metrics, resting-state network and region-to-region functional connectivity patterns, and magnetic resonance spectroscopy absolute metabolite concentrations were ...[more]

PMID: 29070666

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Dataset Information

Multiparametric MRI changes persist beyond recovery in concussed adolescent hockey players.

Objective

Methods

Results

Conclusions

Publications

Multiparametric MRI changes persist beyond recovery in concussed adolescent hockey players.

Similar Datasets

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