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Genetics and Biology of Pancreatic Ductal Adenocarcinoma.

ABSTRACT: Pancreatic ductal adenocarcinoma remains a clinical challenge. Thus far, enlightenment on the downstream activities of Kras, the tumor's unique metabolic needs, and how the stroma and immune system affect it have remained untranslated to the clinical practice. Given the numbers of diverse therapies in development and a growing knowledge about how to evaluate these systems preclinically and clinically, this is expected to change significantly and for the better over the next 5 years.

SUBMITTER: Dunne RF 

PROVIDER: S-EPMC5697145 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Genetics and Biology of Pancreatic Ductal Adenocarcinoma.

Dunne Richard F RF   Hezel Aram F AF  

Hematology/oncology clinics of North America 20150610 4

Pancreatic ductal adenocarcinoma remains a clinical challenge. Thus far, enlightenment on the downstream activities of Kras, the tumor's unique metabolic needs, and how the stroma and immune system affect it have remained untranslated to the clinical practice. Given the numbers of diverse therapies in development and a growing knowledge about how to evaluate these systems preclinically and clinically, this is expected to change significantly and for the better over the next 5 years. ...[more]

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