Ontology highlight
ABSTRACT:
SUBMITTER: Pellesi L
PROVIDER: S-EPMC5697612 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pellesi Lanfranco L Guerzoni Simona S Pini Luigi Alberto LA
Clinical pharmacology in drug development 20170414 6
Migraine, a common neurovascular brain disorder, represents a severe and widespread health problem; along with medication-induced (medication-overuse) headache, it is the third-leading cause of disability worldwide. Currently, its therapeutic management remains unsatisfactory for several reasons; up to 40% of migraineurs are eligible for prophylactic treatment, but there are issues of efficacy, safety, and adherence. In recent years the evidence on the role of calcitonin gene-related peptide (CG ...[more]