Ontology highlight
ABSTRACT:
SUBMITTER: Sheth R
PROVIDER: S-EPMC5697718 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Sheth Rushikesh R Barozzi Iros I Langlais David D Osterwalder Marco M Nemec Stephen S Carlson Hanqian L HL Stadler H Scott HS Visel Axel A Drouin Jacques J Kmita Marie M
Cell reports 20161201 11
The combinatorial expression of Hox genes along the body axes is a major determinant of cell fate and plays a pivotal role in generating the animal body plan. Loss of HOXA13 and HOXD13 transcription factors (HOX13) leads to digit agenesis in mice, but how HOX13 proteins regulate transcriptional outcomes and confer identity to the distal-most limb cells has remained elusive. Here, we report on the genome-wide profiling of HOXA13 and HOXD13 in vivo binding and changes of the transcriptome and chro ...[more]