Ontology highlight
ABSTRACT:
SUBMITTER: Woodruff RS
PROVIDER: S-EPMC5697752 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Woodruff R S RS Ivanov I I Verhamme I M IM Sun M-F MF Gailani D D Sullenger B A BA
Thrombosis research 20170609
<h4>Background</h4>The plasma protease factor XIa (FXIa) has become a target of interest for therapeutics designed to prevent or treat thrombotic disorders.<h4>Methods</h4>We used a solution-based, directed evolution approach called systematic evolution of ligands by exponential enrichment (SELEX) to isolate RNA aptamers that target the FXIa catalytic domain.<h4>Results</h4>Two aptamers, designated 11.16 and 12.7, were identified that bound to previously identified anion binding and serpin bindi ...[more]