Ontology highlight
ABSTRACT:
SUBMITTER: Ridge LA
PROVIDER: S-EPMC5697871 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ridge Liam A LA Mitchell Karen K Al-Anbaki Ali A Shaikh Qureshi Wasay Mohiuddin WM Stephen Louise A LA Tenin Gennadiy G Lu Yinhui Y Lupu Irina-Elena IE Clowes Christopher C Robertson Abigail A Barnes Emma E Wright Jayne A JA Keavney Bernard B Ehler Elisabeth E Lovell Simon C SC Kadler Karl E KE Hentges Kathryn E KE
PLoS genetics 20171030 10
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. The generation of treatments for cardiovascular disease will be aided by a deeper understanding of the developmental processes that underpin coronary vessel formation. From an ENU mutagenesis screen, we have isolated a mouse mutant displaying embryonic hydrocephalus and cardiac defects (EHC). ...[more]