A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste.

ABSTRACT: Fat represents a calorically potent food source that yields approximately twice the amount of energy as carbohydrates or proteins per unit of mass. The highly palatable taste of free fatty acids (FAs), one of the building blocks of fat, promotes food consumption, activates reward circuitry, and is thought to contribute to hedonic feeding underlying many metabolism-related disorders. Despite a role in the etiology of metabolic diseases, little is known about how dietary fats are detected by the gustatory system to promote feeding. Previously, we showed that a broad population of sugar-sensing taste neurons expressing Gustatory Receptor 64f (Gr64f) is required for reflexive feeding responses to both FAs and sugars. Here, we report a genetic silencing screen to identify specific populations o

SUBMITTER: Tauber JM 

PROVIDER: S-EPMC5697886 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature