Ontology highlight
ABSTRACT:
SUBMITTER: Barnes SJ
PROVIDER: S-EPMC5697914 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Barnes Samuel J SJ Franzoni Eleonora E Jacobsen R Irene RI Erdelyi Ferenc F Szabo Gabor G Clopath Claudia C Keller Georg B GB Keck Tara T
Neuron 20171105 4
Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following sensory deprivation in a subset of inhibitory (layer 2/3 GAD65-positive) and excitatory (layer 5 Thy1-positive) neurons in mouse visual cortex. Using repeated in vivo two-photon imaging, we find that increases in spine size are tumor necrosis factor alpha (TNF-α) dependent and ...[more]