Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez JH
PROVIDER: S-EPMC5698065 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Dominguez Jesus H JH Liu Yunlong Y Gao Hongyu H Dominguez James M JM Xie Danhui D Kelly K J KJ
Journal of the American Society of Nephrology : JASN 20170726 12
Ischemic renal injury is a complex syndrome; multiple cellular abnormalities cause accelerating cycles of inflammation, cellular damage, and sustained local ischemia. There is no single therapy that effectively resolves the renal damage after ischemia. However, infusions of normal adult rat renal cells have been a successful therapy in several rat renal failure models. The sustained broad renal benefit achieved by relatively few donor cells led to the hypothesis that extracellular vesicles (EV, ...[more]