SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.

ABSTRACT:

Background

Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to investigate the roles of SIRT2 in aging-related and angiotensin II (Ang II)-induced pathological cardiac hypertrophy.

Methods

Male C57BL/6J wild-type and Sirt2 knockout mice were subjected to the investigation of aging-related cardiac hypertrophy. Cardiac hypertrophy was also induced by Ang II (1.3 mg/kg/d for 4 weeks) in male C57BL/6J Sirt2 knockout mice, cardiac-specific SIRT2 transgenic (SIRT2-Tg) mice, and their respective litte

SUBMITTER: Tang X 

PROVIDER: S-EPMC5698109 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature