Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.
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ABSTRACT:
SUBMITTER: Kang JTL
PROVIDER: S-EPMC5698150 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.
Kang Jonathan T L JTL Goldberg Amy A Edge Michael D MD Behar Doron M DM Rosenberg Noah A NA
Human heredity 20160101 3-4
<h4>Objectives</h4>Recent studies have highlighted the potential of analyses of genomic sharing to produce insight into the demographic processes affecting human populations. We study runs of homozygosity (ROH) in 18 Jewish populations, examining these groups in relation to 123 non-Jewish populations sampled worldwide.<h4>Methods</h4>By sorting ROH into 3 length classes (short, intermediate, and long), we evaluate the impact of demographic processes on genomic patterns in Jewish populations.<h4> ...[more]
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