Ontology highlight
ABSTRACT:
SUBMITTER: Goudsmits JMH
PROVIDER: S-EPMC5698293 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Goudsmits Joris M H JMH Slotboom Dirk Jan DJ van Oijen Antoine M AM
Nature communications 20171121 1
ATP-binding cassette (ABC) transporters form the largest class of active membrane transport proteins. Binding and hydrolysis of ATP by their highly conserved nucleotide-binding domains drive conformational changes of the complex that mediate transport of substrate across the membrane. The vitamin B<sub>12</sub> importer BtuCD-F in Escherichia coli is an extensively studied model system. The periplasmic soluble binding protein BtuF binds the ligand; the transmembrane and ATPase domains BtuCD medi ...[more]