Ontology highlight
ABSTRACT:
SUBMITTER: Mori R
PROVIDER: S-EPMC5698428 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Mori Raffaele R Wauman Joris J Icardi Laura L Van der Heyden José J De Cauwer Lode L Peelman Frank F De Bosscher Karolien K Tavernier Jan J
Scientific reports 20171121 1
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects. Of the STAT-mediated signal transduction pathways, STAT3 transcriptional control is best understood. Jak kinase dependent activation of STAT3 relies on Y705 phosphorylation triggering a conformational switch that is stabilized by intermolecular interactions between SH2 domains and the ...[more]