Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women.

ABSTRACT: Background: Little is known about placental vitamin D metabolism and its impact on maternal circulating vitamin D concentrations in humans.Objective: This study sought to advance the current understanding of placental vitamin D metabolism and its role in modulating maternal circulating vitamin D metabolites during pregnancy.Design: Nested within a feeding study, 24 healthy pregnant women (26-29 wk of gestation) consumed a single amount of vitamin D (511 IU/d from diet and a cholecalciferol supplement) for 10 wk. Concentrations of placental and blood vitamin D metabolites and placental messenger RNA (mRNA) abundance of vitamin D metabolic pathway components were quantified. In addition, cultured human trophoblasts were incubated with ¹³C-cholecalciferol to ex

SUBMITTER: Park H 

PROVIDER: S-EPMC5698837 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature