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Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings.

ABSTRACT: An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8-11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope.

SUBMITTER: Abdelraheem EMM

PROVIDER: S-EPMC5698880 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings.

Abdelraheem Eman M M EMM Madhavachary Rudrakshula R Rossetti Arianna A Kurpiewska Katarzyna K Kalinowska-Tłuścik Justyna J Shaabani Shabnam S Dömling Alexander A

Organic letters 20171030 22

An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8-11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad subs ...[more]

PMID: 29083197

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