Ontology highlight
ABSTRACT:
SUBMITTER: Yarwood RE
PROVIDER: S-EPMC5699040 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Yarwood Rebecca E RE Imlach Wendy L WL Lieu TinaMarie T Veldhuis Nicholas A NA Jensen Dane D DD Klein Herenbrink Carmen C Aurelio Luigi L Cai Zhijian Z Christie MacDonald J MJ Poole Daniel P DP Porter Christopher J H CJH McLean Peter P Hicks Gareth A GA Geppetti Pierangelo P Halls Michelle L ML Canals Meritxell M Bunnett Nigel W NW
Proceedings of the National Academy of Sciences of the United States of America 20171030 46
G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals. Consequently, therapeutic drugs are designed to target GPCRs at the plasma membrane. Activated GPCRs undergo clathrin-dependent endocytosis. Whether GPCRs in endosomes control pathophysiological processes in vivo and are therapeutic targets remains uncertain. We investigated the contribution o ...[more]