The immunopeptidomic landscape of ovarian carcinomas.
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ABSTRACT:
SUBMITTER: Schuster H
PROVIDER: S-EPMC5699044 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
The immunopeptidomic landscape of ovarian carcinomas.
Schuster Heiko H Peper Janet K JK Bösmüller Hans-Christian HC Röhle Kevin K Backert Linus L Bilich Tatjana T Ney Britta B Löffler Markus W MW Kowalewski Daniel J DJ Trautwein Nico N Rabsteyn Armin A Engler Tobias T Braun Sabine S Haen Sebastian P SP Walz Juliane S JS Schmid-Horch Barbara B Brucker Sara Y SY Wallwiener Diethelm D Kohlbacher Oliver O Fend Falko F Rammensee Hans-Georg HG Stevanović Stefan S Staebler Annette A Wagner Philipp P
Proceedings of the National Academy of Sciences of the United States of America 20171101 46
Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer therapy by releasing the power of the immune system. However, only little is known about the antigens that are essentially presented on cancer cells, capable of exposing them to immune cells. Large-scale HLA ligandome analysis has enabled us to exhaustively characterize the immunopeptidomic landscape of epithelial ovarian cancers (EOCs). Additional comparative profiling with the immunopeptidome of a variety ...[more]
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Project description:Immunopeptidome analysis of ovarian carcinoma tissues was performed to characterize the HLA class I and class II presented ligandome of this malignancy.
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