Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC5699052 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Huang Xiaofang X Zhou Xin X Hu Xiaoyu X Joshi Amit S AS Guo Xiangyang X Zhu Yushan Y Chen Quan Q Prinz William A WA Hu Junjie J
Proceedings of the National Academy of Sciences of the United States of America 20171101 46
Mitochondria constantly divide and fuse. Homotypic fusion of the outer mitochondrial membranes requires the mitofusin (MFN) proteins, a family of dynamin-like GTPases. MFNs are anchored in the membrane by transmembrane (TM) segments, exposing both the N-terminal GTPase domain and the C-terminal tail (CT) to the cytosol. This arrangement is very similar to that of the atlastin (ATL) GTPases, which mediate fusion of endoplasmic reticulum (ER) membranes. We engineered various MFN-ATL chimeras to ga ...[more]