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Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

ABSTRACT: A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyl-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, significant progress has characterized Dnmt2-related research. Here, we review this progress in its diverse facets including molecular evolution, structural biology, biochemistry, chemical biology, cell biology and epigenetics.

SUBMITTER: Jeltsch A

PROVIDER: S-EPMC5699548 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

Jeltsch Albert A Ehrenhofer-Murray Ann A Jurkowski Tomasz P TP Lyko Frank F Reuter Gunter G Ankri Serge S Nellen Wolfgang W Schaefer Matthias M Helm Mark M

RNA biology 20160527 9

A group of homologous nucleic acid modification enzymes called Dnmt2, Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a methyl group from the cofactor S-adenosyl-methionine (SAM) to the carbon-5 of cytosine residues. Originally considered as DNA MTases, these enzymes were shown to be tRNA methyltransferases about a decade ago. Between the presumed involvement in DNA modification-related epigenetics, and the recent foray into the RNA modification field, signifi ...[more]

PMID: 27232191

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