Ontology highlight
ABSTRACT:
SUBMITTER: Serrano-Villar S
PROVIDER: S-EPMC5700350 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20171122 12
A low CD4/CD8 ratio during treated HIV infection reflects heightened immune activation and predicts death. The effects of different antiretroviral therapy regimens on CD4/CD8 ratio recovery remains unclear. We performed a <i>post hoc</i> analysis of the MERIT study, a randomized, double-blind trial of maraviroc versus efavirenz in combination with zidovudine-lamivudine in treatment-naive HIV-infected individuals. We found higher rates of CD4/CD8 ratio normalization with efavirenz, which was driv ...[more]