Effects of Maraviroc versus Efavirenz in Combination with Zidovudine-Lamivudine on the CD4/CD8 Ratio in Treatment-Naive HIV-Infected Individuals.
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SUBMITTER: Serrano-Villar S
PROVIDER: S-EPMC5700350 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Effects of Maraviroc versus Efavirenz in Combination with Zidovudine-Lamivudine on the CD4/CD8 Ratio in Treatment-Naive HIV-Infected Individuals.
Serrano-Villar Sergio S Caruana Giorgia G Zlotnik Alexander A Pérez-Molina José A JA Moreno Santiago S
Antimicrobial agents and chemotherapy 20171122 12
A low CD4/CD8 ratio during treated HIV infection reflects heightened immune activation and predicts death. The effects of different antiretroviral therapy regimens on CD4/CD8 ratio recovery remains unclear. We performed a <i>post hoc</i> analysis of the MERIT study, a randomized, double-blind trial of maraviroc versus efavirenz in combination with zidovudine-lamivudine in treatment-naive HIV-infected individuals. We found higher rates of CD4/CD8 ratio normalization with efavirenz, which was driv ...[more]
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