Unknown

Dataset Information

0

Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro.

ABSTRACT: Lung disease caused by Mycobacterium abscessus is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro Synergy was found with a fractional inhibitory concentration index (FICI) score of ?0.5 and a 4- to 10-fold decrease in MIC.

SUBMITTER: Mukherjee D 

PROVIDER: S-EPMC5700366 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Vancomycin and Clarithromycin Show Synergy against <i>Mycobacterium abscessus In Vitro</i>.

Mukherjee Devika D   Wu Mu-Lu ML   Teo Jeanette W P JWP   Dick Thomas T  

Antimicrobial agents and chemotherapy 20171122 12

Lung disease caused by <i>Mycobacterium abscessus</i> is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against <i>M. abscessus</i> complex isolates <i>in vitro</i> Synergy was found with a fractional inhibitory concentration index (FICI) score of ≤0.5 and a 4- to 10-fold decrease in MIC. ...[more]

Similar Datasets

Unknown Omadacycline Potentiates Clarithromycin Activity Against <i>Mycobacterium abscessus</i>.
| S-EPMC8693020 | biostudies-literature
Unknown Assessment of in vitro activities of novel modified antimicrobial peptides against clarithromycin resistant Mycobacterium abscessus
| S-EPMC8592419 | biostudies-literature
Unknown Carbapenems and Rifampin Exhibit Synergy against Mycobacterium tuberculosis and Mycobacterium abscessus.
| S-EPMC4576034 | biostudies-literature
Unknown Rifabutin Acts in Synergy and Is Bactericidal with Frontline Mycobacterium abscessus Antibiotics Clarithromycin and Tigecycline, Suggesting a Potent Treatment Combination.
| S-EPMC6105836 | biostudies-other
Unknown Selection of Resistance to Clarithromycin in Mycobacterium abscessus Subspecies.
| S-EPMC5192163 | biostudies-literature
Unknown Whole-Genome Sequencing for Predicting Clarithromycin Resistance in Mycobacterium abscessus.
| S-EPMC6325232 | biostudies-literature
Unknown Inducible and Acquired Clarithromycin Resistance in the Mycobacterium abscessus Complex.
| S-EPMC4598034 | biostudies-literature
Unknown Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo.
| S-EPMC7778363 | biostudies-literature
Unknown Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant <i>Mycobacterium abscessus</i>.
| S-EPMC8555507 | biostudies-literature
Unknown <i>In Vitro</i> Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus.
| S-EPMC8754139 | biostudies-literature