Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro.
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ABSTRACT:
SUBMITTER: Mukherjee D
PROVIDER: S-EPMC5700366 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Vancomycin and Clarithromycin Show Synergy against <i>Mycobacterium abscessus In Vitro</i>.
Mukherjee Devika D Wu Mu-Lu ML Teo Jeanette W P JWP Dick Thomas T
Antimicrobial agents and chemotherapy 20171122 12
Lung disease caused by <i>Mycobacterium abscessus</i> is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against <i>M. abscessus</i> complex isolates <i>in vitro</i> Synergy was found with a fractional inhibitory concentration index (FICI) score of ≤0.5 and a 4- to 10-fold decrease in MIC. ...[more]
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